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pentobarbital will raise the stage or influence of ivosidenib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. Coadministration of ivosidenib with solid CYP3A4 inducers diminished ivosidenib plasma concentrations.The common each day dose with the barbiturate addict will likely be about one.five grams.